Ablation of TrkA function in the immune system causes B cell abnormalities

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Ablation of TrkA function in the immune system causes B cell abnormalities.

The nerve growth factor (NGF) receptor TrkA is widely expressed in non-neural tissues suggesting pleiotropic functions outside the nervous system. Based on pharmacological and immuno-depletion experiments, it has been hypothesized that NGF plays an important role in the normal development and function of the immune system. However, attempts to unravel these functions by conventional gene target...

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ژورنال

عنوان ژورنال: Development

سال: 2004

ISSN: 1477-9129,0950-1991

DOI: 10.1242/dev.01383